Detailed information of TA system TA244514

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2515761..2516022
• Replicon: chromosome
• Accession: NZ_CP097034
• Organism: Enterococcus faecalis strain AT40b

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: M2913_RS12265
• Protein ID: WP_224561205.1
• Coordinates: 2515921..2516022 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2515761..2515972 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2913_RS12240	2511445..2512398	-	954	WP_002359060.1	siderophore ABC transporter substrate-binding protein	-
M2913_RS12245	2512437..2513192	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
M2913_RS12250	2513189..2514154	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
M2913_RS12255	2514151..2515098	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
M2913_RS12260	2515283..2515735	+	453	WP_002378807.1	YueI family protein	-
-	2515761..2515972	+	212	-	-	Antitoxin
M2913_RS12265	2515921..2516022	-	102	WP_224561205.1	putative holin-like toxin	Toxin
M2913_RS12270	2516213..2518483	-	2271	WP_002378809.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
M2913_RS12275	2518654..2519160	+	507	WP_002378810.1	cysteine hydrolase family protein	-
M2913_RS12280	2519350..2520246	+	897	WP_002365354.1	YitT family protein	-
M2913_RS12285	2520297..2520695	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3629.37 Da
• Isoelectric Point: 4.5869

>T244514 WP_224561205.1 NZ_CP097034:c2516022-2515921 [Enterococcus faecalis]
MSIEATLELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 212 bp

>AT244514 NZ_CP097034:2515761-2515972 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATGAAAATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAAC
ACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGG
TTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin