Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 467907..468139 Replicon chromosome
Accession NZ_CP097034
Organism Enterococcus faecalis strain AT40b

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag M2913_RS02305 Protein ID WP_002355568.1
Coordinates 467907..468023 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 467934..468139 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2913_RS02295 463345..465603 + 2259 WP_002363179.1 DNA helicase PcrA -
M2913_RS02300 465729..467759 + 2031 WP_002378031.1 NAD-dependent DNA ligase LigA -
M2913_RS02305 467907..468023 + 117 WP_002355568.1 putative holin-like toxin Toxin
- 467934..468139 - 206 - - Antitoxin
M2913_RS02310 468341..468646 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
M2913_RS02315 468646..470115 + 1470 WP_002358701.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
M2913_RS02320 470115..471545 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
M2913_RS02325 471564..472652 + 1089 WP_002355572.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T244510 WP_002355568.1 NZ_CP097034:467907-468023 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 206 bp

>AT244510 NZ_CP097034:c468139-467934 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References