Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2660478..2660876 Replicon chromosome
Accession NZ_CP097031
Organism Enterococcus faecalis strain AT41

Toxin (Protein)


Gene name txpA Uniprot ID Q82Z30
Locus tag M2914_RS12765 Protein ID WP_002387585.1
Coordinates 2660733..2660876 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2660478..2660622 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
- (2655757) 2655757..2655933 - 177 NuclAT_14 - -
- (2655791) 2655791..2655945 - 155 NuclAT_7 - -
M2914_RS12755 (2656085) 2656085..2656189 + 105 WP_021164545.1 putative holin-like toxin -
- (2656122) 2656122..2656377 - 256 NuclAT_0 - -
M2914_RS12760 (2656379) 2656379..2660137 - 3759 WP_116495142.1 WxL domain-containing protein -
- (2660478) 2660478..2660622 - 145 NuclAT_5 - Antitoxin
- (2660480) 2660480..2660622 - 143 NuclAT_15 - -
M2914_RS12765 (2660733) 2660733..2660876 + 144 WP_002387585.1 putative holin-like toxin Toxin
- (2660851) 2660851..2661065 - 215 NuclAT_2 - -
- (2661017) 2661017..2661066 + 50 NuclAT_18 - -
- (2660808) 2660808..2661067 - 260 NuclAT_13 - -
M2914_RS12770 (2661067) 2661067..2664111 - 3045 WP_161970605.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5244.37 Da        Isoelectric Point: 10.5719

>T244500 WP_002387585.1 NZ_CP097031:2660733-2660876 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILKVVKEDKKK

Download         Length: 144 bp

Antitoxin


Download         Length: 145 bp

>AT244500 NZ_CP097031:c2660622-2660478 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCTTT
TTAGTTACAAAAAATAACCGTACTCAGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAAGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A059MXV6

Antitoxin

Download structure file

References