Detailed information of TA system TA244493

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2583340..2583733
• Replicon: chromosome
• Accession: NZ_CP097031
• Organism: Enterococcus faecalis strain AT41

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: M2914_RS12425
• Protein ID: WP_002392696.1
• Coordinates: 2583340..2583483 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2583584..2583733 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2914_RS12410 (2578587)	2578587..2579300	-	714	WP_002354877.1	trehalose operon repressor	-
M2914_RS12415 (2579561)	2579561..2582305	+	2745	WP_116495149.1	glycosyl hydrolase family 65 protein	-
M2914_RS12420 (2582320)	2582320..2582970	+	651	WP_002415627.1	beta-phosphoglucomutase	-
- (2583025)	2583025..2583165	+	141	NuclAT_6	-	-
- (2583221)	2583221..2583362	+	142	NuclAT_16	-	-
- (2583221)	2583221..2583407	+	187	NuclAT_1	-	-
M2914_RS12425 (2583340)	2583340..2583483	-	144	WP_002392696.1	type I toxin-antitoxin system toxin PepG1	Toxin
- (2583596)	2583596..2583730	+	135	NuclAT_17	-	-
- (2583584)	2583584..2583733	+	150	NuclAT_3	-	Antitoxin
M2914_RS12430 (2584006)	2584006..2584599	+	594	WP_161970597.1	PBECR4 domain-containing protein	-
- (2584722)	2584722..2584862	+	141	NuclAT_4	-	-
M2914_RS12435 (2585361)	2585361..2585894	+	534	WP_002416003.1	CPBP family intramembrane metalloprotease	-
M2914_RS12440 (2585948)	2585948..2586919	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
M2914_RS12445 (2587094)	2587094..2587531	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
M2914_RS12450 (2587664)	2587664..2588218	-	555	WP_002378827.1	nucleoside triphosphate pyrophosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T244493 WP_002392696.1 NZ_CP097031:c2583483-2583340 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 150 bp

>AT244493 NZ_CP097031:2583584-2583733 [Enterococcus faecalis]
TTTTTAGGGAAATGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGA
CGGTGACCGATTGTATTATTTAAAAATAACCGTACTCGGTCAAAGTTGACGGTTATTTTTTATTGTCATT

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin