244490

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2583025..2583483 Replicon chromosome
Accession NZ_CP097031
Organism Enterococcus faecalis strain AT41

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag M2914_RS12425 Protein ID WP_002392696.1
Coordinates 2583340..2583483 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2583025..2583165 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2914_RS12410 (2578587) 2578587..2579300 - 714 WP_002354877.1 trehalose operon repressor -
M2914_RS12415 (2579561) 2579561..2582305 + 2745 WP_116495149.1 glycosyl hydrolase family 65 protein -
M2914_RS12420 (2582320) 2582320..2582970 + 651 WP_002415627.1 beta-phosphoglucomutase -
- (2583025) 2583025..2583165 + 141 NuclAT_6 - Antitoxin
- (2583221) 2583221..2583362 + 142 NuclAT_16 - -
- (2583221) 2583221..2583407 + 187 NuclAT_1 - -
M2914_RS12425 (2583340) 2583340..2583483 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
- (2583596) 2583596..2583730 + 135 NuclAT_17 - -
- (2583584) 2583584..2583733 + 150 NuclAT_3 - -
M2914_RS12430 (2584006) 2584006..2584599 + 594 WP_161970597.1 PBECR4 domain-containing protein -
- (2584722) 2584722..2584862 + 141 NuclAT_4 - -
M2914_RS12435 (2585361) 2585361..2585894 + 534 WP_002416003.1 CPBP family intramembrane metalloprotease -
M2914_RS12440 (2585948) 2585948..2586919 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
M2914_RS12445 (2587094) 2587094..2587531 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
M2914_RS12450 (2587664) 2587664..2588218 - 555 WP_002378827.1 nucleoside triphosphate pyrophosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T244490 WP_002392696.1 NZ_CP097031:c2583483-2583340 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 141 bp

>AT244490 NZ_CP097031:2583025-2583165 [Enterococcus faecalis]
TGCTAGAATGTAGATGAAAAGAGAGATATGCGTCAACGTACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACTTTTTGA
ATTATTTAAAAATAACCGTACTCGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References