Detailed information of TA system TA244486

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2518960..2519440
• Replicon: chromosome
• Accession: NZ_CP097031
• Organism: Enterococcus faecalis strain AT41

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: M2914_RS12125
• Protein ID: WP_228088368.1
• Coordinates: 2518960..2519061 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2519236..2519440 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2914_RS12100 (2514489)	2514489..2515442	-	954	WP_116495158.1	siderophore ABC transporter substrate-binding protein	-
M2914_RS12105 (2515481)	2515481..2516236	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
M2914_RS12110 (2516233)	2516233..2517198	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
M2914_RS12115 (2517195)	2517195..2518142	-	948	WP_002394759.1	iron chelate uptake ABC transporter family permease subunit	-
M2914_RS12120 (2518326)	2518326..2518778	+	453	WP_010707017.1	YueI family protein	-
- (2518804)	2518804..2519011	+	208	NuclAT_11	-	-
- (2518841)	2518841..2519015	+	175	NuclAT_20	-	-
M2914_RS12125 (2518960)	2518960..2519061	-	102	WP_228088368.1	putative holin-like toxin	Toxin
- (2519236)	2519236..2519440	+	205	NuclAT_12	-	Antitoxin
- (2519270)	2519270..2519457	+	188	NuclAT_19	-	-
M2914_RS12130 (2519394)	2519394..2519495	-	102	WP_021164442.1	putative holin-like toxin	-
M2914_RS12135 (2519686)	2519686..2521956	-	2271	WP_116495157.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
M2914_RS12140 (2522127)	2522127..2522627	+	501	WP_002378961.1	cysteine hydrolase family protein	-
M2914_RS12145 (2522973)	2522973..2523869	+	897	WP_002354953.1	YitT family protein	-
M2914_RS12150 (2523920)	2523920..2524318	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3628.39 Da
• Isoelectric Point: 6.0656

>T244486 WP_228088368.1 NZ_CP097031:c2519061-2518960 [Enterococcus faecalis]
MSIEATLELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 205 bp

>AT244486 NZ_CP097031:2519236-2519440 [Enterococcus faecalis]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACAC
CAGTTATAAGAACTGGTGGCTTACTGTGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTT
ATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTA

Structures

Antitoxin