244482

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 462574..462806 Replicon chromosome
Accession NZ_CP097031
Organism Enterococcus faecalis strain AT41

Toxin (Protein)


Gene name txpA Uniprot ID Q837V5
Locus tag M2914_RS02270 Protein ID WP_002366178.1
Coordinates 462574..462690 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 462601..462806 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2914_RS02260 (458012) 458012..460270 + 2259 WP_116495118.1 DNA helicase PcrA -
M2914_RS02265 (460396) 460396..462426 + 2031 WP_116495119.1 NAD-dependent DNA ligase LigA -
M2914_RS02270 (462574) 462574..462690 + 117 WP_002366178.1 putative holin-like toxin Toxin
- (462601) 462601..462806 - 206 NuclAT_10 - Antitoxin
M2914_RS02275 (463008) 463008..463313 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
M2914_RS02280 (463313) 463313..464782 + 1470 WP_002361259.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
M2914_RS02285 (464782) 464782..466212 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
M2914_RS02290 (466231) 466231..467319 + 1089 WP_002355572.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4108.01 Da        Isoelectric Point: 5.9482

>T244482 WP_002366178.1 NZ_CP097031:462574-462690 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFVILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 206 bp

>AT244482 NZ_CP097031:c462806-462601 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAA
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1G1S9M0

Antitoxin

Download structure file

References