Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2681038..2681488 Replicon chromosome
Accession NZ_CP097030
Organism Enterococcus faecalis strain AT43a

Toxin (Protein)


Gene name txpA Uniprot ID C7CYQ7
Locus tag M2915_RS12720 Protein ID WP_002358966.1
Coordinates 2681291..2681488 (+) Length 66 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2681038..2681245 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2915_RS12700 (2676614) 2676614..2677246 - 633 WP_002358972.1 RloB family protein -
M2915_RS12705 (2677255) 2677255..2678550 - 1296 WP_002396787.1 ATP-binding protein -
M2915_RS12710 (2679012) 2679012..2680628 + 1617 WP_002358967.1 phosphatase PAP2/LCP family protein -
M2915_RS12715 (2680983) 2680983..2681105 + 123 WP_002404776.1 putative holin-like toxin -
- (2681171) 2681171..2681234 - 64 NuclAT_10 - -
- (2681038) 2681038..2681245 - 208 NuclAT_7 - Antitoxin
M2915_RS12720 (2681291) 2681291..2681488 + 198 WP_002358966.1 type I toxin-antitoxin system toxin PepG1 Toxin
- (2681421) 2681421..2681605 - 185 NuclAT_6 - -
- (2681462) 2681462..2681605 - 144 NuclAT_9 - -
M2915_RS12725 (2681607) 2681607..2681747 + 141 WP_077143780.1 putative holin-like toxin -
- (2681680) 2681680..2681881 - 202 NuclAT_4 - -
M2915_RS12730 (2681978) 2681978..2682121 + 144 WP_002396786.1 putative holin-like toxin -
- (2682265) 2682265..2682314 + 50 NuclAT_11 - -
- (2682053) 2682053..2682315 - 263 NuclAT_8 - -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(32-65)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7571.21 Da        Isoelectric Point: 10.8134

>T244465 WP_002358966.1 NZ_CP097030:2681291-2681488 [Enterococcus faecalis]
MCREVMAVAIQSEREVMRMHVFPKFRERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Download         Length: 198 bp

Antitoxin


Download         Length: 208 bp

>AT244465 NZ_CP097030:c2681245-2681038 [Enterococcus faecalis]
TTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTACTAA
TGGTGACAAAATTTTAAAGATTTTGAAATGACCGTCTAACTAGGCAAAGTTAAACAGCGGTCATTTCTTTTTGTCTTCTT
TAAGCAATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C7CYQ7

Antitoxin

Download structure file

References