Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2586494..2586754 Replicon chromosome
Accession NZ_CP097030
Organism Enterococcus faecalis strain AT43a

Toxin (Protein)


Gene name txpA Uniprot ID -
Locus tag M2915_RS12275 Protein ID WP_156194032.1
Coordinates 2586611..2586754 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2586494..2586678 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2915_RS12260 (2582055) 2582055..2582768 - 714 WP_002354877.1 trehalose operon repressor -
M2915_RS12265 (2583030) 2583030..2585774 + 2745 WP_002404790.1 glycosyl hydrolase family 65 protein -
M2915_RS12270 (2585789) 2585789..2586439 + 651 WP_002359015.1 beta-phosphoglucomutase -
- (2586494) 2586494..2586678 + 185 NuclAT_5 - Antitoxin
M2915_RS12275 (2586611) 2586611..2586754 - 144 WP_156194032.1 type I toxin-antitoxin system toxin PepG1 Toxin
M2915_RS12280 (2586985) 2586985..2587956 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
M2915_RS12285 (2588131) 2588131..2588568 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
M2915_RS12290 (2588701) 2588701..2589255 - 555 WP_002359011.1 Maf family protein -
M2915_RS12295 (2589280) 2589280..2591412 - 2133 WP_085366626.1 DNA mismatch repair endonuclease MutL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5327.50 Da        Isoelectric Point: 10.8331

>T244459 WP_156194032.1 NZ_CP097030:c2586754-2586611 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTISLIALIVKLLKNDKKK

Download         Length: 144 bp

Antitoxin


Download         Length: 185 bp

>AT244459 NZ_CP097030:2586494-2586678 [Enterococcus faecalis]
TGCTAGAATGTAGATGAAAAGAGAGAGATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTGAGACGGTGACCAATTGT
ATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGAAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References