Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 506435..506667 Replicon chromosome
Accession NZ_CP097030
Organism Enterococcus faecalis strain AT43a

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag M2915_RS02480 Protein ID WP_002355568.1
Coordinates 506435..506551 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 506462..506667 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2915_RS02470 (501873) 501873..504131 + 2259 WP_010708284.1 DNA helicase PcrA -
M2915_RS02475 (504257) 504257..506287 + 2031 WP_002358699.1 NAD-dependent DNA ligase LigA -
M2915_RS02480 (506435) 506435..506551 + 117 WP_002355568.1 putative holin-like toxin Toxin
- (506462) 506462..506667 - 206 NuclAT_2 - Antitoxin
M2915_RS02485 (506869) 506869..507174 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
M2915_RS02490 (507174) 507174..508643 + 1470 WP_002358701.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
M2915_RS02495 (508643) 508643..510073 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
M2915_RS02500 (510092) 510092..511180 + 1089 WP_002383001.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T244457 WP_002355568.1 NZ_CP097030:506435-506551 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 206 bp

>AT244457 NZ_CP097030:c506667-506462 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References