Detailed information of TA system TA244438

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2662332..2662615
• Replicon: chromosome
• Accession: NZ_CP097020
• Organism: Enterococcus faecalis strain AT46a

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: M2918_RS12645
• Protein ID: WP_002411240.1
• Coordinates: 2662332..2662481 (+)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2662414..2662615 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2918_RS12625 (2657550)	2657550..2657765	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
M2918_RS12630 (2657904)	2657904..2658896	+	993	WP_002378862.1	biotin--[acetyl-CoA-carboxylase] ligase	-
M2918_RS12635 (2659063)	2659063..2659701	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
M2918_RS12640 (2660387)	2660387..2662003	+	1617	WP_174114069.1	phosphatase PAP2/LCP family protein	-
M2918_RS12645 (2662332)	2662332..2662481	+	150	WP_002411240.1	type I toxin-antitoxin system toxin PepG1	Toxin
- (2662455)	2662455..2662601	-	147	NuclAT_12	-	-
- (2662414)	2662414..2662615	-	202	NuclAT_8	-	Antitoxin
M2918_RS12650 (2662712)	2662712..2662855	+	144	WP_016619108.1	putative holin-like toxin	-
- (2662999)	2662999..2663048	+	50	NuclAT_16	-	-
- (2662787)	2662787..2663049	-	263	NuclAT_11	-	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (16-49)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5738.05 Da
• Isoelectric Point: 11.3858

>T244438 WP_002411240.1 NZ_CP097020:2662332-2662481 [Enterococcus faecalis]
MRMHVFPKFRERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 150 bp

Antitoxin

Nucleotide

• Length: 202 bp

>AT244438 NZ_CP097020:c2662615-2662414 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Structures

Antitoxin