Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2571362..2571636 Replicon chromosome
Accession NZ_CP097020
Organism Enterococcus faecalis strain AT46a

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag M2918_RS12220 Protein ID WP_002392696.1
Coordinates 2571493..2571636 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2571362..2571560 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2918_RS12200 (2566367) 2566367..2567080 - 714 WP_002354877.1 trehalose operon repressor -
M2918_RS12205 (2567341) 2567341..2570085 + 2745 WP_174113967.1 glycoside hydrolase family 65 protein -
M2918_RS12210 (2570100) 2570100..2570750 + 651 WP_002354875.1 beta-phosphoglucomutase -
- (2570819) 2570819..2570952 + 134 NuclAT_15 - -
- (2570999) 2570999..2571144 + 146 NuclAT_13 - -
- (2570999) 2570999..2571185 + 187 NuclAT_10 - -
M2918_RS12215 (2571118) 2571118..2571261 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 -
- (2571374) 2571374..2571519 + 146 NuclAT_14 - -
- (2571362) 2571362..2571560 + 199 NuclAT_9 - Antitoxin
M2918_RS12220 (2571493) 2571493..2571636 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
M2918_RS13500 (2572044) 2572044..2572169 - 126 WP_002383214.1 hypothetical protein -
M2918_RS12225 (2572374) 2572374..2572580 + 207 WP_258075960.1 CPBP family intramembrane metalloprotease -
M2918_RS12230 (2572633) 2572633..2573604 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
M2918_RS12235 (2573779) 2573779..2574216 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
M2918_RS12240 (2574349) 2574349..2574903 - 555 WP_002354869.1 Maf family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T244435 WP_002392696.1 NZ_CP097020:c2571636-2571493 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 199 bp

>AT244435 NZ_CP097020:2571362-2571560 [Enterococcus faecalis]
TTTTTAGGGAAATGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGA
CGGTGACCGATTATATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References