Detailed information of TA system TA244423

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2496064..2496321
• Replicon: chromosome
• Accession: NZ_CP097020
• Organism: Enterococcus faecalis strain AT46a

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: M2918_RS11860
• Protein ID: WP_021164441.1
• Coordinates: 2496220..2496321 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2496064..2496271 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2918_RS11835 (2491748)	2491748..2492701	-	954	WP_174114190.1	siderophore ABC transporter substrate-binding protein	-
M2918_RS11840 (2492740)	2492740..2493495	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
M2918_RS11845 (2493492)	2493492..2494457	-	966	WP_002354961.1	iron chelate uptake ABC transporter family permease subunit	-
M2918_RS11850 (2494454)	2494454..2495401	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
M2918_RS11855 (2495586)	2495586..2496038	+	453	WP_002354958.1	YueI family protein	-
- (2496064)	2496064..2496271	+	208	NuclAT_4	-	Antitoxin
- (2496101)	2496101..2496275	+	175	NuclAT_7	-	-
M2918_RS11860 (2496220)	2496220..2496321	-	102	WP_021164441.1	putative holin-like toxin	Toxin
- (2496496)	2496496..2496706	+	211	NuclAT_5	-	-
- (2496530)	2496530..2496710	+	181	NuclAT_6	-	-
M2918_RS11865 (2496655)	2496655..2496756	-	102	WP_224561205.1	putative holin-like toxin	-
M2918_RS11870 (2496946)	2496946..2499216	-	2271	WP_002368430.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
M2918_RS11875 (2499387)	2499387..2499893	+	507	WP_174114188.1	cysteine hydrolase family protein	-
M2918_RS11880 (2500083)	2500083..2500979	+	897	WP_002368434.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3598.36 Da
• Isoelectric Point: 6.0656

>T244423 WP_021164441.1 NZ_CP097020:c2496321-2496220 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 208 bp

>AT244423 NZ_CP097020:2496064-2496271 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATAAAGATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAAC
ACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTAT
TTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin