Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 912258..912595 Replicon chromosome
Accession NZ_CP097010
Organism Enterococcus faecalis strain AT48

Toxin (Protein)


Gene name txpA Uniprot ID A0A1J6YG70
Locus tag M2921_RS04235 Protein ID WP_002396786.1
Coordinates 912258..912401 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 912333..912595 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2921_RS04225 907590..907694 + 105 WP_021164545.1 putative holin-like toxin -
M2921_RS04230 907884..911663 - 3780 WP_010818049.1 WxL domain-containing protein -
M2921_RS04235 912258..912401 + 144 WP_002396786.1 putative holin-like toxin Toxin
- 912333..912595 - 263 - - Antitoxin
M2921_RS04240 912595..915654 - 3060 WP_002398514.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5203.19 Da        Isoelectric Point: 8.6626

>T244408 WP_002396786.1 NZ_CP097010:912258-912401 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 263 bp

>AT244408 NZ_CP097010:c912595-912333 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTATA
ATAGCATTGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6YG70

Antitoxin

Download structure file

References