Detailed information of TA system TA244405

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 912004..912401
• Replicon: chromosome
• Accession: NZ_CP097010
• Organism: Enterococcus faecalis strain AT48

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A1J6YG70
• Locus tag: M2921_RS04235
• Protein ID: WP_002396786.1
• Coordinates: 912258..912401 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	912004..912161 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2921_RS04225	907590..907694	+	105	WP_021164545.1	putative holin-like toxin	-
M2921_RS04230	907884..911663	-	3780	WP_010818049.1	WxL domain-containing protein	-
-	912004..912161	-	158	-	-	Antitoxin
M2921_RS04235	912258..912401	+	144	WP_002396786.1	putative holin-like toxin	Toxin
M2921_RS04240	912595..915654	-	3060	WP_002398514.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5203.19 Da
• Isoelectric Point: 8.6626

>T244405 WP_002396786.1 NZ_CP097010:912258-912401 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

Antitoxin

Nucleotide

• Length: 158 bp

>AT244405 NZ_CP097010:c912161-912004 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTTA
AGACGGTGACCCGTTATTATTTAAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTCAGC

Structures

Toxin

• AlphaFold DB: A0A1J6YG70

Antitoxin