Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 829069..829331 Replicon chromosome
Accession NZ_CP097010
Organism Enterococcus faecalis strain AT48

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag M2921_RS03885 Protein ID WP_002392696.1
Coordinates 829188..829331 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 829069..829214 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2921_RS03870 824484..827228 + 2745 WP_025189669.1 glycosyl hydrolase family 65 protein -
M2921_RS03875 827243..827893 + 651 WP_002398182.1 beta-phosphoglucomutase -
M2921_RS03880 828355..828948 + 594 WP_002398183.1 PBECR4 domain-containing protein -
- 829069..829214 + 146 - - Antitoxin
M2921_RS03885 829188..829331 - 144 WP_002392696.1 type I toxin-antitoxin system toxin PepG1 Toxin
M2921_RS03890 829563..830534 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
M2921_RS03895 830709..831146 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
M2921_RS03900 831279..831833 - 555 WP_002354869.1 Maf family protein -
M2921_RS03905 831858..833990 - 2133 WP_010716772.1 DNA mismatch repair endonuclease MutL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T244399 WP_002392696.1 NZ_CP097010:c829331-829188 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 146 bp

>AT244399 NZ_CP097010:829069-829214 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References