Detailed information of TA system TA244395

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 760279..760502
• Replicon: chromosome
• Accession: NZ_CP097010
• Organism: Enterococcus faecalis strain AT48

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: M2921_RS03550
• Protein ID: WP_075551663.1
• Coordinates: 760401..760502 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	760279..760456 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2921_RS03525	755926..756879	-	954	WP_002375576.1	siderophore ABC transporter substrate-binding protein	-
M2921_RS03530	756918..757673	-	756	WP_248860219.1	ATP-binding cassette domain-containing protein	-
M2921_RS03535	757670..758635	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
M2921_RS03540	758632..759579	-	948	WP_010716775.1	iron chelate uptake ABC transporter family permease subunit	-
M2921_RS03545	759764..760216	+	453	WP_002354958.1	YueI family protein	-
-	760279..760456	+	178	-	-	Antitoxin
M2921_RS03550	760401..760502	-	102	WP_075551663.1	putative holin-like toxin	Toxin
M2921_RS03555	760834..760935	-	102	WP_075551663.1	putative holin-like toxin	-
M2921_RS03560	761125..763395	-	2271	WP_002398160.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
M2921_RS03565	763566..764066	+	501	WP_002365352.1	cysteine hydrolase family protein	-
M2921_RS03570	764369..765265	+	897	WP_002354953.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T244395 WP_075551663.1 NZ_CP097010:c760502-760401 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 178 bp

>AT244395 NZ_CP097010:760279-760456 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGA
AAATCAGTAGTGCAACAA

Structures

Antitoxin