244390

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2622030..2622367 Replicon chromosome
Accession NZ_CP097008
Organism Enterococcus faecalis strain AT50

Toxin (Protein)


Gene name txpA Uniprot ID A0A1J6YG70
Locus tag M2923_RS12335 Protein ID WP_002396786.1
Coordinates 2622030..2622173 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2622105..2622367 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2923_RS12320 (2617746) 2617746..2618378 - 633 WP_002358972.1 RloB family protein -
M2923_RS12325 (2618387) 2618387..2619682 - 1296 WP_002410675.1 ATP-binding protein -
M2923_RS12330 (2620144) 2620144..2621760 + 1617 WP_002372620.1 phosphatase PAP2/LCP family protein -
M2923_RS12335 (2622030) 2622030..2622173 + 144 WP_002396786.1 putative holin-like toxin Toxin
- (2622317) 2622317..2622366 + 50 NuclAT_8 - -
- (2622105) 2622105..2622367 - 263 NuclAT_7 - Antitoxin
M2923_RS12340 (2622368) 2622368..2627059 - 4692 WP_248857869.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5203.19 Da        Isoelectric Point: 8.6626

>T244390 WP_002396786.1 NZ_CP097008:2622030-2622173 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

Antitoxin


Download         Length: 263 bp

>AT244390 NZ_CP097008:c2622367-2622105 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGACAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6YG70

Antitoxin

Download structure file

References