Detailed information of TA system TA244381

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2462668..2462925
• Replicon: chromosome
• Accession: NZ_CP097008
• Organism: Enterococcus faecalis strain AT50

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: M2923_RS11610
• Protein ID: WP_021164441.1
• Coordinates: 2462824..2462925 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2462668..2462875 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2923_RS11585 (2458352)	2458352..2459305	-	954	WP_010709946.1	siderophore ABC transporter substrate-binding protein	-
M2923_RS11590 (2459344)	2459344..2460099	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
M2923_RS11595 (2460096)	2460096..2461061	-	966	WP_016622541.1	iron chelate uptake ABC transporter family permease subunit	-
M2923_RS11600 (2461058)	2461058..2462005	-	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
M2923_RS11605 (2462190)	2462190..2462642	+	453	WP_002359057.1	YueI family protein	-
- (2462668)	2462668..2462875	+	208	NuclAT_3	-	Antitoxin
- (2462705)	2462705..2462879	+	175	NuclAT_6	-	-
M2923_RS11610 (2462824)	2462824..2462925	-	102	WP_021164441.1	putative holin-like toxin	Toxin
- (2463100)	2463100..2463309	+	210	NuclAT_4	-	-
- (2463134)	2463134..2463313	+	180	NuclAT_5	-	-
M2923_RS11615 (2463258)	2463258..2463359	-	102	WP_075551663.1	putative holin-like toxin	-
M2923_RS11620 (2463547)	2463547..2465817	-	2271	WP_002368430.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
M2923_RS11625 (2465988)	2465988..2466488	+	501	WP_010709949.1	cysteine hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3598.36 Da
• Isoelectric Point: 6.0656

>T244381 WP_021164441.1 NZ_CP097008:c2462925-2462824 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 208 bp

>AT244381 NZ_CP097008:2462668-2462875 [Enterococcus faecalis]
TTCCATTTATAATAGAATTATGCTATTATAAAGATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAAC
ACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTAT
TTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin