244379

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 495003..495235 Replicon chromosome
Accession NZ_CP097008
Organism Enterococcus faecalis strain AT50

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag M2923_RS02410 Protein ID WP_002355568.1
Coordinates 495003..495119 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 495030..495235 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2923_RS02400 (490441) 490441..492699 + 2259 WP_002363179.1 DNA helicase PcrA -
M2923_RS02405 (492825) 492825..494855 + 2031 WP_002364804.1 NAD-dependent DNA ligase LigA -
M2923_RS02410 (495003) 495003..495119 + 117 WP_002355568.1 putative holin-like toxin Toxin
- (495030) 495030..495235 - 206 NuclAT_2 - Antitoxin
M2923_RS02415 (495437) 495437..495742 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
M2923_RS02420 (495742) 495742..497220 + 1479 WP_016622625.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
M2923_RS02425 (497210) 497210..498640 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
M2923_RS02430 (498659) 498659..499747 + 1089 WP_002355572.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T244379 WP_002355568.1 NZ_CP097008:495003-495119 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 206 bp

>AT244379 NZ_CP097008:c495235-495030 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References