Detailed information of TA system TA244363

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2464710..2464971
• Replicon: chromosome
• Accession: NZ_CP097006
• Organism: Enterococcus faecalis strain LS05-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: M2924_RS11555
• Protein ID: WP_162780856.1
• Coordinates: 2464870..2464971 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2464710..2464916 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2924_RS11530 (2460365)	2460365..2461318	-	954	WP_002375576.1	siderophore ABC transporter substrate-binding protein	-
M2924_RS11535 (2461357)	2461357..2462112	-	756	WP_002375575.1	ATP-binding cassette domain-containing protein	-
M2924_RS11540 (2462109)	2462109..2463074	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
M2924_RS11545 (2463071)	2463071..2464018	-	948	WP_002375573.1	iron chelate uptake ABC transporter family permease subunit	-
M2924_RS11550 (2464202)	2464202..2464654	+	453	WP_002375572.1	YueI family protein	-
- (2464710)	2464710..2464916	+	207	NuclAT_7	-	Antitoxin
- (2464747)	2464747..2464933	+	187	NuclAT_9	-	-
M2924_RS11555 (2464870)	2464870..2464971	-	102	WP_162780856.1	putative holin-like toxin	Toxin
M2924_RS11560 (2465163)	2465163..2467433	-	2271	WP_002368430.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
M2924_RS11565 (2467604)	2467604..2468104	+	501	WP_002395960.1	cysteine hydrolase family protein	-
M2924_RS11570 (2468903)	2468903..2469799	+	897	WP_002368434.1	YitT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3624.40 Da
• Isoelectric Point: 6.0656

>T244363 WP_162780856.1 NZ_CP097006:c2464971-2464870 [Enterococcus faecalis]
MSIEATLELMISFATLVALLIFGILEATKNNKK

Nucleotide

• Length: 102 bp

Antitoxin

Nucleotide

• Length: 207 bp

>AT244363 NZ_CP097006:2464710-2464916 [Enterococcus faecalis]
TTCCATTTATAATAGAATTGTGCTATTATGAAGATGAAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTATACCAGCG
CCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGG
TTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTA

Structures

Antitoxin