Detailed information of TA system TA244361

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2518544..2518942
• Replicon: chromosome
• Accession: NZ_CP097004
• Organism: Enterococcus faecalis strain LS05-2

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: M2925_RS11965
• Protein ID: WP_023894767.1
• Coordinates: 2518544..2518648 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2518800..2518942 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M2925_RS11950 (2513856)	2513856..2514569	-	714	WP_002354877.1	trehalose operon repressor	-
M2925_RS11955 (2514830)	2514830..2517574	+	2745	WP_219259715.1	glycosyl hydrolase family 65 protein	-
M2925_RS11960 (2517589)	2517589..2518239	+	651	WP_002419627.1	beta-phosphoglucomutase	-
- (2518268)	2518268..2518382	+	115	NuclAT_11	-	-
- (2518424)	2518424..2518611	+	188	NuclAT_4	-	-
M2925_RS11965 (2518544)	2518544..2518648	-	105	WP_023894767.1	putative holin-like toxin	Toxin
- (2518800)	2518800..2518942	+	143	NuclAT_10	-	Antitoxin
M2925_RS12880 (2519033)	2519033..2519155	-	123	WP_258536616.1	hypothetical protein	-
M2925_RS11970 (2519696)	2519696..2519971	+	276	WP_224805966.1	CPBP family intramembrane metalloprotease	-
M2925_RS11975 (2520027)	2520027..2520998	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
M2925_RS11980 (2521173)	2521173..2521610	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
M2925_RS11985 (2521743)	2521743..2522297	-	555	WP_010816844.1	Maf family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-34)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3799.63 Da
• Isoelectric Point: 10.0079

>T244361 WP_023894767.1 NZ_CP097004:c2518648-2518544 [Enterococcus faecalis]
MSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 105 bp

Antitoxin

Nucleotide

• Length: 143 bp

>AT244361 NZ_CP097004:2518800-2518942 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACCGATCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAACA

Structures

Antitoxin