244353

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 461306..461538 Replicon chromosome
Accession NZ_CP097004
Organism Enterococcus faecalis strain LS05-2

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag M2925_RS02285 Protein ID WP_002355568.1
Coordinates 461306..461422 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 461333..461538 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2925_RS02275 (456744) 456744..459002 + 2259 WP_002363179.1 DNA helicase PcrA -
M2925_RS02280 (459128) 459128..461158 + 2031 WP_002375948.1 NAD-dependent DNA ligase LigA -
M2925_RS02285 (461306) 461306..461422 + 117 WP_002355568.1 putative holin-like toxin Toxin
- (461333) 461333..461538 - 206 NuclAT_3 - Antitoxin
- (461405) 461405..461540 - 136 NuclAT_9 - -
- (461405) 461405..461560 - 156 NuclAT_7 - -
M2925_RS02290 (461740) 461740..462045 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
M2925_RS02295 (462045) 462045..463514 + 1470 WP_002419989.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
M2925_RS02300 (463514) 463514..464944 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
M2925_RS02305 (464963) 464963..466051 + 1089 WP_002383001.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T244353 WP_002355568.1 NZ_CP097004:461306-461422 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

Antitoxin


Download         Length: 206 bp

>AT244353 NZ_CP097004:c461538-461333 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACCAGTTATAAGAACTGGTGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGCGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References