Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 5042539..5043141 Replicon chromosome
Accession NZ_CP096976
Organism Escherichia coli strain 17-07187

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag M2894_RS24530 Protein ID WP_000897305.1
Coordinates 5042830..5043141 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M2894_RS24525 Protein ID WP_000356397.1
Coordinates 5042539..5042829 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2894_RS24500 (5038483) 5038483..5039385 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
M2894_RS24505 (5039382) 5039382..5040017 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
M2894_RS24510 (5040014) 5040014..5040943 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
M2894_RS24515 (5041273) 5041273..5041515 - 243 WP_001087409.1 protein YiiF -
M2894_RS24520 (5041735) 5041735..5041953 - 219 WP_001315930.1 CopG family transcriptional regulator -
M2894_RS24525 (5042539) 5042539..5042829 - 291 WP_000356397.1 NadS family protein Antitoxin
M2894_RS24530 (5042830) 5042830..5043141 - 312 WP_000897305.1 hypothetical protein Toxin
M2894_RS24535 (5043370) 5043370..5044278 + 909 WP_001387201.1 alpha/beta hydrolase -
M2894_RS24540 (5044342) 5044342..5045283 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
M2894_RS24545 (5045328) 5045328..5045765 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
M2894_RS24550 (5045762) 5045762..5046634 - 873 WP_000920762.1 virulence factor BrkB family protein -
M2894_RS24555 (5046628) 5046628..5047227 - 600 WP_001295269.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T244334 WP_000897305.1 NZ_CP096976:c5043141-5042830 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT244334 WP_000356397.1 NZ_CP096976:c5042829-5042539 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References