Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 718356..719155 Replicon chromosome
Accession NZ_CP096976
Organism Escherichia coli strain 17-07187

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag M2894_RS03495 Protein ID WP_000347267.1
Coordinates 718356..718820 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag M2894_RS03500 Protein ID WP_001307405.1
Coordinates 718820..719155 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2894_RS03465 (713357) 713357..713791 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
M2894_RS03470 (713809) 713809..714687 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
M2894_RS03475 (714677) 714677..715456 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
M2894_RS03480 (715467) 715467..715940 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
M2894_RS03485 (715963) 715963..717243 - 1281 WP_000681935.1 tagatose-bisphosphate aldolase subunit KbaZ -
M2894_RS03490 (717492) 717492..718301 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
M2894_RS03495 (718356) 718356..718820 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
M2894_RS03500 (718820) 718820..719155 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
M2894_RS03505 (719304) 719304..720875 - 1572 WP_001273741.1 galactarate dehydratase -
M2894_RS03510 (721249) 721249..722583 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
M2894_RS03515 (722599) 722599..723369 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T244311 WP_000347267.1 NZ_CP096976:c718820-718356 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT244311 WP_001307405.1 NZ_CP096976:c719155-718820 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References