244291

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1274028..1274650 Replicon chromosome
Accession NZ_CP096964
Organism Pseudomonas aeruginosa strain NY13936

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M2J01_RS05980 Protein ID WP_023910260.1
Coordinates 1274028..1274342 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M2J01_RS05985 Protein ID WP_023910258.1
Coordinates 1274345..1274650 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2J01_RS05950 (M2J01_05950) 1269064..1270020 + 957 WP_236079379.1 site-specific integrase -
M2J01_RS05955 (M2J01_05955) 1270089..1270400 + 312 WP_031631670.1 outer membrane protein assembly factor BamE -
M2J01_RS05960 (M2J01_05960) 1270532..1271182 + 651 WP_058172679.1 BRCT domain-containing protein -
M2J01_RS05965 (M2J01_05965) 1271280..1271558 + 279 WP_121333592.1 hypothetical protein -
M2J01_RS05970 (M2J01_05970) 1271619..1272781 + 1163 WP_086937300.1 IS3-like element IS222 family transposase -
M2J01_RS05975 (M2J01_05975) 1272801..1273250 - 450 WP_058167335.1 GNAT family N-acetyltransferase -
M2J01_RS05980 (M2J01_05980) 1274028..1274342 + 315 WP_023910260.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2J01_RS05985 (M2J01_05985) 1274345..1274650 + 306 WP_023910258.1 helix-turn-helix domain-containing protein Antitoxin
M2J01_RS05990 (M2J01_05990) 1274711..1275010 - 300 WP_058172668.1 hypothetical protein -
M2J01_RS05995 (M2J01_05995) 1275111..1275323 - 213 WP_121333665.1 hypothetical protein -
M2J01_RS06000 (M2J01_06000) 1275320..1277200 - 1881 WP_121333664.1 DNA cytosine methyltransferase -
M2J01_RS06005 (M2J01_06005) 1277197..1277676 - 480 WP_023094641.1 hypothetical protein -
M2J01_RS06010 (M2J01_06010) 1277686..1277925 - 240 WP_019396882.1 hypothetical protein -
M2J01_RS06015 (M2J01_06015) 1277922..1278548 - 627 WP_121333387.1 hypothetical protein -
M2J01_RS06020 (M2J01_06020) 1278599..1278916 - 318 WP_019726489.1 pyocin activator PrtN family protein -
M2J01_RS06025 (M2J01_06025) 1278913..1279143 - 231 WP_019726488.1 hypothetical protein -
M2J01_RS06030 (M2J01_06030) 1279294..1279587 - 294 WP_121337895.1 phage antirepressor KilAC domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1264963..1313053 48090


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-72)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11776.54 Da        Isoelectric Point: 9.4385

>T244291 WP_023910260.1 NZ_CP096964:1274028-1274342 [Pseudomonas aeruginosa]
MIFIETPVFTKRILALVDDETYRKLQEDLTLHPDAGVVIEGTGGVRKIRIAANGHGKRGGARVIYYHFTSASQIAFLLAY
DKASQEDLTADQKKMLRQIVENWR

Download         Length: 315 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11316.84 Da        Isoelectric Point: 7.2077

>AT244291 WP_023910258.1 NZ_CP096964:1274345-1274650 [Pseudomonas aeruginosa]
MDKELFAELVESVTQMDEIVRGERQPSREFHVDAVKVKEIRRATGLSQAKFARKIDVAVGTLRNWEQGRRDPEGPARALL
RAIDNDPVHVLAALNGGPRES

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References