Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5393929..5394524 Replicon chromosome
Accession NZ_CP096961
Organism Pseudomonas aeruginosa strain NY13932

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag M2J00_RS25000 Protein ID WP_003113526.1
Coordinates 5394246..5394524 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M2J00_RS24995 Protein ID WP_003113527.1
Coordinates 5393929..5394234 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2J00_RS24975 (M2J00_24915) 5389260..5389550 - 291 WP_270036334.1 DUF5447 family protein -
M2J00_RS24980 (M2J00_24920) 5389762..5390034 - 273 WP_003115921.1 hypothetical protein -
M2J00_RS24985 (M2J00_24925) 5390481..5390816 + 336 WP_121496269.1 hypothetical protein -
M2J00_RS24990 (M2J00_24930) 5390890..5393250 - 2361 WP_162950028.1 ATP-binding protein -
M2J00_RS24995 (M2J00_24935) 5393929..5394234 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
M2J00_RS25000 (M2J00_24940) 5394246..5394524 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2J00_RS25005 (M2J00_24945) 5394577..5394705 - 129 Protein_4939 integrase -
M2J00_RS25010 (M2J00_24950) 5394853..5397081 + 2229 WP_003099265.1 TonB-dependent receptor -
M2J00_RS25015 (M2J00_24955) 5397151..5397798 - 648 WP_003095021.1 carbonate dehydratase -
M2J00_RS25020 (M2J00_24960) 5397860..5399098 - 1239 WP_023084819.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T244288 WP_003113526.1 NZ_CP096961:c5394524-5394246 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT244288 WP_003113527.1 NZ_CP096961:c5394234-5393929 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References