Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4711079..4711760 Replicon chromosome
Accession NZ_CP096961
Organism Pseudomonas aeruginosa strain NY13932

Toxin (Protein)


Gene name higB Uniprot ID V6AKP0
Locus tag M2J00_RS21800 Protein ID WP_003111825.1
Coordinates 4711395..4711760 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M2J00_RS21795 Protein ID WP_003145733.1
Coordinates 4711079..4711402 (-) Length 108 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2J00_RS21770 (M2J00_21720) 4706992..4707630 + 639 WP_003109444.1 hypothetical protein -
M2J00_RS21775 (M2J00_21725) 4707873..4708208 + 336 WP_003140884.1 TM2 domain-containing protein -
M2J00_RS21780 (M2J00_21730) 4708382..4708900 + 519 WP_128654462.1 PAAR domain-containing protein -
M2J00_RS21785 (M2J00_21735) 4708897..4709598 + 702 WP_003111822.1 VRR-NUC domain-containing protein -
M2J00_RS21790 (M2J00_21740) 4709615..4710703 + 1089 WP_034025227.1 DUF3396 domain-containing protein -
M2J00_RS21795 (M2J00_21745) 4711079..4711402 - 324 WP_003145733.1 XRE family transcriptional regulator Antitoxin
M2J00_RS21800 (M2J00_21750) 4711395..4711760 - 366 WP_003111825.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2J00_RS21805 (M2J00_21755) 4712024..4712263 - 240 WP_049876884.1 hypothetical protein -
M2J00_RS21810 (M2J00_21760) 4712470..4712742 + 273 WP_003085667.1 hypothetical protein -
M2J00_RS21815 (M2J00_21765) 4712761..4713186 - 426 WP_003114206.1 VOC family protein -
M2J00_RS21820 (M2J00_21770) 4713287..4714171 + 885 WP_128654463.1 LysR substrate-binding domain-containing protein -
M2J00_RS21825 (M2J00_21775) 4714144..4715097 - 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
M2J00_RS21830 (M2J00_21780) 4715318..4715752 + 435 WP_003116494.1 RidA family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-106)

Antitoxin

(33-63)


Sequences


Toxin        


Download         Length: 122 a.a.        Molecular weight: 13880.24 Da        Isoelectric Point: 4.8219

>T244287 WP_003111825.1 NZ_CP096961:c4711760-4711395 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRHGHMRELRTQHGGRPFRTLYAFDPRRSA
ILLIGGDKTGDDRWYELNVPIADRLYDEHLHQLREEGLIDG

Download         Length: 366 bp


Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11896.73 Da        Isoelectric Point: 6.4751

>AT244287 WP_003145733.1 NZ_CP096961:c4711402-4711079 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V6AKP0


Antitoxin

Source ID Structure

References