Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5980967..5981562 Replicon chromosome
Accession NZ_CP096960
Organism Pseudomonas aeruginosa strain NY11254

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag M2I99_RS28225 Protein ID WP_003113526.1
Coordinates 5981284..5981562 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M2I99_RS28220 Protein ID WP_003133769.1
Coordinates 5980967..5981272 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I99_RS28205 (M2I99_28140) 5977673..5978536 - 864 WP_031761182.1 integrase domain-containing protein -
M2I99_RS28210 (M2I99_28145) 5979137..5980294 - 1158 WP_031761183.1 STY4528 family pathogenicity island replication protein -
M2I99_RS28220 (M2I99_28155) 5980967..5981272 - 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
M2I99_RS28225 (M2I99_28160) 5981284..5981562 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2I99_RS28230 (M2I99_28165) 5981615..5981743 - 129 Protein_5581 integrase -
M2I99_RS28235 (M2I99_28170) 5981891..5984119 + 2229 WP_023104079.1 TonB-dependent receptor -
M2I99_RS28240 (M2I99_28175) 5984190..5984837 - 648 WP_003095021.1 carbonate dehydratase -
M2I99_RS28245 (M2I99_28180) 5984899..5986137 - 1239 WP_003095023.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T244281 WP_003113526.1 NZ_CP096960:c5981562-5981284 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT244281 WP_003133769.1 NZ_CP096960:c5981272-5980967 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References