Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5546788..5547383 Replicon chromosome
Accession NZ_CP096956
Organism Pseudomonas aeruginosa strain NY11173

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag M2I96_RS26040 Protein ID WP_003113526.1
Coordinates 5547105..5547383 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M2I96_RS26035 Protein ID WP_003113527.1
Coordinates 5546788..5547093 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I96_RS26000 (M2I96_25920) 5541929..5542777 + 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
M2I96_RS26010 (M2I96_25930) 5542944..5543885 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
M2I96_RS26015 (M2I96_25935) 5544002..5544616 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
M2I96_RS26020 (M2I96_25940) 5544658..5545242 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
M2I96_RS26025 (M2I96_25945) 5545283..5546383 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
M2I96_RS26035 (M2I96_25955) 5546788..5547093 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
M2I96_RS26040 (M2I96_25960) 5547105..5547383 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2I96_RS26045 (M2I96_25965) 5547436..5547564 - 129 Protein_5145 integrase -
M2I96_RS26050 (M2I96_25970) 5547712..5549940 + 2229 WP_003099265.1 TonB-dependent receptor -
M2I96_RS26055 (M2I96_25975) 5550010..5550657 - 648 WP_003095021.1 carbonate dehydratase -
M2I96_RS26060 (M2I96_25980) 5550719..5551957 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T244265 WP_003113526.1 NZ_CP096956:c5547383-5547105 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT244265 WP_003113527.1 NZ_CP096956:c5547093-5546788 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References