Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4822294..4822975 Replicon chromosome
Accession NZ_CP096956
Organism Pseudomonas aeruginosa strain NY11173

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M2I96_RS22525 Protein ID WP_015503432.1
Coordinates 4822610..4822975 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M2I96_RS22520 Protein ID WP_016561576.1
Coordinates 4822294..4822617 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I96_RS22485 (M2I96_22415) 4817915..4818793 + 879 WP_003109435.1 hypothetical protein -
M2I96_RS22495 (M2I96_22425) 4819305..4820171 - 867 WP_023081971.1 hypothetical protein -
M2I96_RS22500 (M2I96_22430) 4820201..4820452 - 252 WP_124136459.1 hypothetical protein -
M2I96_RS22505 (M2I96_22435) 4820669..4821672 - 1004 Protein_4452 tyrosine-type recombinase/integrase -
M2I96_RS22510 (M2I96_22440) 4821672..4822064 - 393 Protein_4453 hypothetical protein -
M2I96_RS22515 (M2I96_22445) 4822059..4822178 + 120 Protein_4454 IS5/IS1182 family transposase -
M2I96_RS22520 (M2I96_22450) 4822294..4822617 - 324 WP_016561576.1 XRE family transcriptional regulator Antitoxin
M2I96_RS22525 (M2I96_22455) 4822610..4822975 - 366 WP_015503432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2I96_RS22530 (M2I96_22460) 4823239..4823481 - 243 WP_043884955.1 hypothetical protein -
M2I96_RS22535 (M2I96_22465) 4823688..4823960 + 273 WP_003085667.1 hypothetical protein -
M2I96_RS22540 (M2I96_22470) 4823979..4824404 - 426 WP_003163196.1 VOC family protein -
M2I96_RS22545 (M2I96_22475) 4824505..4825389 + 885 WP_019725847.1 LysR substrate-binding domain-containing protein -
M2I96_RS22550 (M2I96_22480) 4825362..4826315 - 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
M2I96_RS22555 (M2I96_22485) 4826536..4826970 + 435 WP_003158601.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13798.14 Da        Isoelectric Point: 4.8219

>T244263 WP_015503432.1 NZ_CP096956:c4822975-4822610 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRPGHMRELRTQHGGRPFRTLYAFDPRRSA
ILPIGGDKTGDDRWYELNVPIADRLHDEHLHQLREEGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11903.72 Da        Isoelectric Point: 5.8900

>AT244263 WP_016561576.1 NZ_CP096956:c4822617-4822294 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQSRGLSQKMLSEVLQVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References