Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5781962..5782557 Replicon chromosome
Accession NZ_CP096953
Organism Pseudomonas aeruginosa strain NY5535

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag M2I95_RS27675 Protein ID WP_003117425.1
Coordinates 5782279..5782557 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M2I95_RS27670 Protein ID WP_003113527.1
Coordinates 5781962..5782267 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I95_RS27635 (M2I95_27505) 5777102..5777950 + 849 WP_023122792.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
M2I95_RS27645 (M2I95_27515) 5778117..5779058 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
M2I95_RS27650 (M2I95_27520) 5779175..5779789 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
M2I95_RS27655 (M2I95_27525) 5779831..5780415 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
M2I95_RS27660 (M2I95_27530) 5780456..5781556 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
M2I95_RS27670 (M2I95_27540) 5781962..5782267 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
M2I95_RS27675 (M2I95_27545) 5782279..5782557 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2I95_RS27680 (M2I95_27550) 5782610..5782738 - 129 Protein_5474 integrase -
M2I95_RS27685 (M2I95_27555) 5782886..5785114 + 2229 WP_003099265.1 TonB-dependent receptor -
M2I95_RS27690 (M2I95_27560) 5785184..5785831 - 648 WP_003095021.1 carbonate dehydratase -
M2I95_RS27695 (M2I95_27565) 5785893..5787131 - 1239 WP_031685043.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T244258 WP_003117425.1 NZ_CP096953:c5782557-5782279 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT244258 WP_003113527.1 NZ_CP096953:c5782267-5781962 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References