Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5758043..5758638 Replicon chromosome
Accession NZ_CP096950
Organism Pseudomonas aeruginosa strain NY5532

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag M2I94_RS27265 Protein ID WP_003113526.1
Coordinates 5758360..5758638 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M2I94_RS27260 Protein ID WP_003113527.1
Coordinates 5758043..5758348 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I94_RS27240 (M2I94_27145) 5754119..5754376 + 258 WP_010793759.1 ATP-binding protein -
M2I94_RS27245 (M2I94_27150) 5754752..5755615 - 864 WP_010793758.1 integrase domain-containing protein -
M2I94_RS27250 (M2I94_27155) 5756217..5757359 - 1143 WP_010793757.1 STY4528 family pathogenicity island replication protein -
M2I94_RS27260 (M2I94_27165) 5758043..5758348 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
M2I94_RS27265 (M2I94_27170) 5758360..5758638 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2I94_RS27270 (M2I94_27175) 5758691..5758819 - 129 Protein_5391 integrase -
M2I94_RS27275 (M2I94_27180) 5758967..5761195 + 2229 WP_003099265.1 TonB-dependent receptor -
M2I94_RS27280 (M2I94_27185) 5761265..5761912 - 648 WP_003095021.1 carbonate dehydratase -
M2I94_RS27285 (M2I94_27190) 5761974..5763212 - 1239 WP_010793756.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T244251 WP_003113526.1 NZ_CP096950:c5758638-5758360 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT244251 WP_003113527.1 NZ_CP096950:c5758348-5758043 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References