Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5816265..5816860 Replicon chromosome
Accession NZ_CP096946
Organism Pseudomonas aeruginosa strain NY5530

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M2I93_RS27345 Protein ID WP_270004088.1
Coordinates 5816582..5816860 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M2I93_RS27340 Protein ID WP_003113527.1
Coordinates 5816265..5816570 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I93_RS27305 (M2I93_27260) 5811405..5812253 + 849 WP_023122792.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
M2I93_RS27315 (M2I93_27270) 5812420..5813361 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
M2I93_RS27320 (M2I93_27275) 5813478..5814092 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
M2I93_RS27325 (M2I93_27280) 5814134..5814718 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
M2I93_RS27330 (M2I93_27285) 5814759..5815859 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
M2I93_RS27340 (M2I93_27295) 5816265..5816570 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
M2I93_RS27345 (M2I93_27300) 5816582..5816860 - 279 WP_270004088.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2I93_RS27350 (M2I93_27305) 5816913..5817041 - 129 Protein_5408 integrase -
M2I93_RS27355 (M2I93_27310) 5817189..5819417 + 2229 WP_003099265.1 TonB-dependent receptor -
M2I93_RS27360 (M2I93_27315) 5819487..5820134 - 648 WP_003095021.1 carbonate dehydratase -
M2I93_RS27365 (M2I93_27320) 5820196..5821434 - 1239 WP_270030464.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10671.25 Da        Isoelectric Point: 8.5576

>T244243 WP_270004088.1 NZ_CP096946:c5816860-5816582 [Pseudomonas aeruginosa]
MILAFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT244243 WP_003113527.1 NZ_CP096946:c5816570-5816265 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References