Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5681825..5682420 Replicon chromosome
Accession NZ_CP096945
Organism Pseudomonas aeruginosa strain NY5525

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag M2I92_RS27315 Protein ID WP_003117425.1
Coordinates 5682142..5682420 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M2I92_RS27310 Protein ID WP_003113527.1
Coordinates 5681825..5682130 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I92_RS27270 (M2I92_27190) 5676989..5677280 - 292 Protein_5393 DUF5447 family protein -
M2I92_RS27275 (M2I92_27195) 5677284..5677496 - 213 WP_058181545.1 hypothetical protein -
M2I92_RS27280 (M2I92_27200) 5677498..5677713 - 216 WP_058181544.1 DNA-binding protein -
M2I92_RS27285 (M2I92_27205) 5677847..5678114 + 268 Protein_5396 DNA-binding protein -
M2I92_RS27290 (M2I92_27210) 5678259..5678780 + 522 WP_152992837.1 hypothetical protein -
M2I92_RS27295 (M2I92_27215) 5678824..5679426 - 603 WP_071538272.1 hypothetical protein -
M2I92_RS27300 (M2I92_27220) 5679591..5680391 + 801 WP_283859153.1 protein kinase -
M2I92_RS27305 (M2I92_27225) 5680388..5681461 + 1074 WP_003113528.1 serine/threonine-protein kinase -
M2I92_RS27310 (M2I92_27230) 5681825..5682130 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
M2I92_RS27315 (M2I92_27235) 5682142..5682420 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2I92_RS27320 (M2I92_27240) 5682473..5682601 - 129 Protein_5403 integrase -
M2I92_RS27325 (M2I92_27245) 5682749..5684977 + 2229 WP_003099265.1 TonB-dependent receptor -
M2I92_RS27330 (M2I92_27250) 5685047..5685694 - 648 WP_003095021.1 carbonate dehydratase -
M2I92_RS27335 (M2I92_27255) 5685756..5686994 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T244238 WP_003117425.1 NZ_CP096945:c5682420-5682142 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT244238 WP_003113527.1 NZ_CP096945:c5682130-5681825 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References