244231

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 6112385..6112980 Replicon chromosome
Accession NZ_CP096942
Organism Pseudomonas aeruginosa strain NY5524

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag M2I87_RS29510 Protein ID WP_003113526.1
Coordinates 6112702..6112980 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M2I87_RS29505 Protein ID WP_003113527.1
Coordinates 6112385..6112690 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I87_RS29485 (M2I87_29350) 6108461..6108718 + 258 WP_010793759.1 ATP-binding protein -
M2I87_RS29490 (M2I87_29355) 6109094..6109957 - 864 WP_010793758.1 integrase domain-containing protein -
M2I87_RS29495 (M2I87_29360) 6110559..6111701 - 1143 WP_010793757.1 STY4528 family pathogenicity island replication protein -
M2I87_RS29505 (M2I87_29370) 6112385..6112690 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
M2I87_RS29510 (M2I87_29375) 6112702..6112980 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2I87_RS29515 (M2I87_29380) 6113033..6113161 - 129 Protein_5839 integrase -
M2I87_RS29520 (M2I87_29385) 6113309..6115537 + 2229 WP_003099265.1 TonB-dependent receptor -
M2I87_RS29525 (M2I87_29390) 6115607..6116254 - 648 WP_003095021.1 carbonate dehydratase -
M2I87_RS29530 (M2I87_29395) 6116316..6117554 - 1239 WP_010793756.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T244231 WP_003113526.1 NZ_CP096942:c6112980-6112702 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT244231 WP_003113527.1 NZ_CP096942:c6112690-6112385 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References