24423

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2508045..2508229 Replicon chromosome
Accession NC_013450
Organism Staphylococcus aureus subsp. aureus ED98

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag SAAV_RS12865 Protein ID WP_000482652.1
Coordinates 2508122..2508229 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2508045..2508105 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAAV_RS12840 2503500..2503667 - 168 Protein_2429 hypothetical protein -
SAAV_RS12850 2503898..2505631 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
SAAV_RS12855 2505656..2507419 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2508045..2508105 + 61 - - Antitoxin
SAAV_RS12865 2508122..2508229 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
SAAV_RS12870 2508363..2508749 - 387 WP_000779360.1 flippase GtxA -
SAAV_RS12875 2509017..2510159 + 1143 WP_001176863.1 glycerate kinase -
SAAV_RS12880 2510219..2510878 + 660 WP_000831298.1 membrane protein -
SAAV_RS12885 2511060..2512271 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
SAAV_RS12890 2512394..2512867 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T24423 WP_000482652.1 NC_013450:c2508229-2508122 [Staphylococcus aureus subsp. aureus ED98]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T24423 NC_013450:c2508229-2508122 [Staphylococcus aureus subsp. aureus ED98]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT24423 NC_013450:2508045-2508105 [Staphylococcus aureus subsp. aureus ED98]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References