Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2609965..2610467 Replicon chromosome
Accession NZ_CP096942
Organism Pseudomonas aeruginosa strain NY5524

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1C7CBF7
Locus tag M2I87_RS12815 Protein ID WP_023081358.1
Coordinates 2610213..2610467 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1C7C600
Locus tag M2I87_RS12810 Protein ID WP_004350479.1
Coordinates 2609965..2610216 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I87_RS12785 (M2I87_12725) 2605077..2605721 + 645 WP_003090351.1 UvrY/SirA/GacA family response regulator transcription factor -
M2I87_RS12790 (M2I87_12730) 2605722..2607548 + 1827 WP_003162160.1 excinuclease ABC subunit UvrC -
M2I87_RS12795 (M2I87_12735) 2607582..2608142 + 561 WP_003090349.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
M2I87_RS12805 (M2I87_12745) 2608510..2609742 + 1233 Protein_2532 tyrosine-type recombinase/integrase -
M2I87_RS12810 (M2I87_12750) 2609965..2610216 + 252 WP_004350479.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
M2I87_RS12815 (M2I87_12755) 2610213..2610467 + 255 WP_023081358.1 Txe/YoeB family addiction module toxin Toxin
M2I87_RS12820 (M2I87_12760) 2610693..2611088 + 396 WP_023081357.1 DUF3742 family protein -
M2I87_RS12825 (M2I87_12765) 2611096..2612616 - 1521 WP_004350477.1 conjugal transfer protein TraG N-terminal domain-containing protein -
M2I87_RS12830 (M2I87_12770) 2612631..2612981 - 351 WP_023081356.1 hypothetical protein -
M2I87_RS12835 (M2I87_12775) 2613169..2614032 - 864 WP_004350470.1 integrase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10061.50 Da        Isoelectric Point: 8.4789

>T244226 WP_023081358.1 NZ_CP096942:2610213-2610467 [Pseudomonas aeruginosa]
VKLIWSEQAWDDYLYWQDTDKRMVKKVNELIKDACRTPFEGKGKPEPLRHNLAGFWSRRITAEHRFVYSVTDDALLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9363.65 Da        Isoelectric Point: 4.5843

>AT244226 WP_004350479.1 NZ_CP096942:2609965-2610216 [Pseudomonas aeruginosa]
MRTISYTEARQNLSATMMKTVEDRAPILITRQNGEACVLMSLEEFNALEETAYLLRSPANARRLMDSIDSLKQGQGVERD
LAE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C7CBF7

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C600

References