244205

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5709551..5710146 Replicon chromosome
Accession NZ_CP096932
Organism Pseudomonas aeruginosa strain NY5510

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag M2I84_RS27105 Protein ID WP_003117425.1
Coordinates 5709868..5710146 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M2I84_RS27100 Protein ID WP_003113527.1
Coordinates 5709551..5709856 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I84_RS27065 (M2I84_27000) 5704691..5705539 + 849 WP_023122792.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
M2I84_RS27075 (M2I84_27010) 5705706..5706647 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
M2I84_RS27080 (M2I84_27015) 5706764..5707378 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
M2I84_RS27085 (M2I84_27020) 5707420..5708004 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
M2I84_RS27090 (M2I84_27025) 5708045..5709145 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
M2I84_RS27100 (M2I84_27035) 5709551..5709856 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
M2I84_RS27105 (M2I84_27040) 5709868..5710146 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2I84_RS27110 (M2I84_27045) 5710199..5710327 - 129 Protein_5360 integrase -
M2I84_RS27115 (M2I84_27050) 5710475..5712703 + 2229 WP_003099265.1 TonB-dependent receptor -
M2I84_RS27120 (M2I84_27055) 5712773..5713420 - 648 WP_003095021.1 carbonate dehydratase -
M2I84_RS27125 (M2I84_27060) 5713482..5714720 - 1239 WP_031685043.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T244205 WP_003117425.1 NZ_CP096932:c5710146-5709868 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT244205 WP_003113527.1 NZ_CP096932:c5709856-5709551 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References