Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5816935..5817530 Replicon chromosome
Accession NZ_CP096929
Organism Pseudomonas aeruginosa strain NY5507

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M2I83_RS27370 Protein ID WP_270004088.1
Coordinates 5817252..5817530 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M2I83_RS27365 Protein ID WP_003113527.1
Coordinates 5816935..5817240 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I83_RS27330 (M2I83_27285) 5812075..5812923 + 849 WP_023122792.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
M2I83_RS27340 (M2I83_27295) 5813090..5814031 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
M2I83_RS27345 (M2I83_27300) 5814148..5814762 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
M2I83_RS27350 (M2I83_27305) 5814804..5815388 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
M2I83_RS27355 (M2I83_27310) 5815429..5816529 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
M2I83_RS27365 (M2I83_27320) 5816935..5817240 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
M2I83_RS27370 (M2I83_27325) 5817252..5817530 - 279 WP_270004088.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2I83_RS27375 (M2I83_27330) 5817583..5817711 - 129 Protein_5413 integrase -
M2I83_RS27380 (M2I83_27335) 5817859..5820087 + 2229 WP_003099265.1 TonB-dependent receptor -
M2I83_RS27385 (M2I83_27340) 5820157..5820804 - 648 WP_003095021.1 carbonate dehydratase -
M2I83_RS27390 (M2I83_27345) 5820866..5822104 - 1239 WP_270030464.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10671.25 Da        Isoelectric Point: 8.5576

>T244200 WP_270004088.1 NZ_CP096929:c5817530-5817252 [Pseudomonas aeruginosa]
MILAFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT244200 WP_003113527.1 NZ_CP096929:c5817240-5816935 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References