244194

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5308895..5309490 Replicon chromosome
Accession NZ_CP096927
Organism Pseudomonas aeruginosa strain NY5506

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag M2I82_RS24630 Protein ID WP_003113526.1
Coordinates 5309212..5309490 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M2I82_RS24625 Protein ID WP_003099268.1
Coordinates 5308895..5309200 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2I82_RS24590 (M2I82_24525) 5304035..5304883 + 849 WP_023115601.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
M2I82_RS24600 (M2I82_24535) 5305050..5305991 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
M2I82_RS24605 (M2I82_24540) 5306108..5306722 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
M2I82_RS24610 (M2I82_24545) 5306764..5307348 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
M2I82_RS24615 (M2I82_24550) 5307389..5308489 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
M2I82_RS24625 (M2I82_24560) 5308895..5309200 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
M2I82_RS24630 (M2I82_24565) 5309212..5309490 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2I82_RS24635 (M2I82_24570) 5309543..5309671 - 129 Protein_4866 integrase -
M2I82_RS24640 (M2I82_24575) 5309819..5312047 + 2229 WP_031633241.1 TonB-dependent receptor -
M2I82_RS24645 (M2I82_24580) 5312117..5312764 - 648 WP_003095021.1 carbonate dehydratase -
M2I82_RS24650 (M2I82_24585) 5312826..5314064 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T244194 WP_003113526.1 NZ_CP096927:c5309490-5309212 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT244194 WP_003099268.1 NZ_CP096927:c5309200-5308895 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References