Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3510..4106 Replicon plasmid pNY11312-NR
Accession NZ_CP096917
Organism Alcaligenes faecalis strain NY11312

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag M2J83_RS21165 Protein ID WP_270120488.1
Coordinates 3510..3788 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M2J83_RS21170 Protein ID WP_270120482.1
Coordinates 3798..4106 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2J83_RS21150 (M2J83_21135) 23..955 + 933 WP_270120477.1 plasmid replication initiator TrfA -
M2J83_RS21155 (M2J83_21140) 1853..2092 - 240 WP_270120479.1 hypothetical protein -
M2J83_RS21160 (M2J83_21145) 2207..3175 + 969 WP_270120481.1 DNA-binding protein -
M2J83_RS21165 (M2J83_21150) 3510..3788 + 279 WP_270120488.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2J83_RS21170 (M2J83_21155) 3798..4106 + 309 WP_270120482.1 HigA family addiction module antitoxin Antitoxin
M2J83_RS21175 (M2J83_21160) 4318..4590 - 273 WP_270120483.1 hypothetical protein -
M2J83_RS21180 (M2J83_21165) 4987..5343 + 357 WP_270120484.1 hypothetical protein -
M2J83_RS21185 (M2J83_21170) 5333..7093 + 1761 WP_270120486.1 type IV secretion system DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..20322 20322


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(24-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10756.30 Da        Isoelectric Point: 8.5710

>T244169 WP_270120488.1 NZ_CP096917:3510-3788 [Alcaligenes faecalis]
MIHSFTCLDTEALFRSQVVPRFKNIERVARRKLLQIHAATELASLRVPPGNQLEALKGDRRGQHSIRINDQWRICFVWHD
DGAHQVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11651.49 Da        Isoelectric Point: 6.6440

>AT244169 WP_270120482.1 NZ_CP096917:3798-4106 [Alcaligenes faecalis]
MAELLDEIHPGEILLEDFMKPMGISARQLAADIDVSPSRISDLVHGNRPITADTALRLGLFFNMEPRFWMNLQTEYDMRV
AARTVREKIAPRIRVFHHHAAA

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References