Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 6042853..6043448 Replicon chromosome
Accession NZ_CP096913
Organism Pseudomonas aeruginosa strain NY7610

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag M2J79_RS28525 Protein ID WP_003113526.1
Coordinates 6043170..6043448 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M2J79_RS28520 Protein ID WP_003133769.1
Coordinates 6042853..6043158 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2J79_RS28490 (M2J79_28460) 6037967..6038920 - 954 WP_023085605.1 PDR/VanB family oxidoreductase -
M2J79_RS28495 (M2J79_28465) 6038921..6039958 - 1038 WP_023085606.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
M2J79_RS28500 (M2J79_28470) 6039980..6040858 - 879 WP_023085607.1 polysaccharide deacetylase -
M2J79_RS28505 (M2J79_28475) 6040884..6041633 - 750 WP_023085608.1 SDR family oxidoreductase -
M2J79_RS28510 (M2J79_28480) 6041635..6042330 - 696 WP_023085609.1 SDR family oxidoreductase -
M2J79_RS28520 (M2J79_28490) 6042853..6043158 - 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
M2J79_RS28525 (M2J79_28495) 6043170..6043448 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2J79_RS28530 (M2J79_28500) 6043501..6043629 - 129 Protein_5642 integrase -
M2J79_RS28535 (M2J79_28505) 6043777..6046005 + 2229 WP_003141628.1 TonB-dependent receptor -
M2J79_RS28540 (M2J79_28510) 6046075..6046722 - 648 WP_003095021.1 carbonate dehydratase -
M2J79_RS28545 (M2J79_28515) 6046784..6048022 - 1239 WP_003141631.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T244163 WP_003113526.1 NZ_CP096913:c6043448-6043170 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT244163 WP_003133769.1 NZ_CP096913:c6043158-6042853 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References