Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5765951..5766546 Replicon chromosome
Accession NZ_CP096909
Organism Pseudomonas aeruginosa strain NY8688

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M2J77_RS27135 Protein ID WP_071538299.1
Coordinates 5766268..5766546 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M2J77_RS27130 Protein ID WP_003123432.1
Coordinates 5765951..5766256 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2J77_RS27085 (M2J77_27020) 5761953..5762018 - 66 Protein_5355 hypothetical protein -
M2J77_RS27090 (M2J77_27025) 5762088..5762315 - 228 WP_153274454.1 hypothetical protein -
M2J77_RS27095 (M2J77_27030) 5762369..5762899 - 531 WP_256824629.1 3'-5' exonuclease -
M2J77_RS27100 (M2J77_27035) 5762989..5763480 - 492 WP_130027294.1 HAD domain-containing protein -
M2J77_RS27105 (M2J77_27040) 5763477..5764046 - 570 WP_130027295.1 HAD-IA family hydrolase -
M2J77_RS27110 (M2J77_27045) 5764057..5764260 - 204 WP_130027297.1 hypothetical protein -
M2J77_RS27115 (M2J77_27050) 5764262..5764822 - 561 WP_130027299.1 hypothetical protein -
M2J77_RS27120 (M2J77_27055) 5764853..5765263 + 411 WP_130027301.1 hypothetical protein -
M2J77_RS27130 (M2J77_27065) 5765951..5766256 - 306 WP_003123432.1 HigA family addiction module antitoxin Antitoxin
M2J77_RS27135 (M2J77_27070) 5766268..5766546 - 279 WP_071538299.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2J77_RS27140 (M2J77_27075) 5766599..5766727 - 129 Protein_5365 integrase -
M2J77_RS27145 (M2J77_27080) 5766875..5769103 + 2229 WP_003113525.1 TonB-dependent receptor -
M2J77_RS27150 (M2J77_27085) 5769173..5769820 - 648 WP_003095021.1 carbonate dehydratase -
M2J77_RS27155 (M2J77_27090) 5769882..5771120 - 1239 WP_003123433.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10616.17 Da        Isoelectric Point: 7.8937

>T244149 WP_071538299.1 NZ_CP096909:c5766546-5766268 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHGIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11204.78 Da        Isoelectric Point: 4.7769

>AT244149 WP_003123432.1 NZ_CP096909:c5766256-5765951 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References