Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 4361870..4362686 Replicon chromosome
Accession NZ_CP096905
Organism Citrobacter amalonaticus strain RSHH22

Toxin (Protein)


Gene name yhaV Uniprot ID A0A8H9VGC4
Locus tag M2R49_RS21045 Protein ID WP_044327726.1
Coordinates 4361870..4362346 (-) Length 159 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A3Q8DNJ3
Locus tag M2R49_RS21050 Protein ID WP_042999108.1
Coordinates 4362351..4362686 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2R49_RS21025 (M2R49_21010) 4356975..4357718 - 744 WP_044264050.1 molecular chaperone -
M2R49_RS21030 (M2R49_21015) 4357761..4360205 - 2445 WP_224267598.1 fimbria/pilus outer membrane usher protein -
M2R49_RS21035 (M2R49_21020) 4360299..4360847 - 549 WP_052443907.1 fimbrial protein -
M2R49_RS21040 (M2R49_21025) 4360916..4361446 - 531 WP_042999110.1 fimbrial protein -
M2R49_RS21045 (M2R49_21030) 4361870..4362346 - 477 WP_044327726.1 type II toxin-antitoxin system YhaV family toxin Toxin
M2R49_RS21050 (M2R49_21035) 4362351..4362686 - 336 WP_042999108.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
M2R49_RS21055 (M2R49_21040) 4362901..4363437 - 537 WP_042999107.1 ferredoxin-type protein NapF -
M2R49_RS21060 (M2R49_21045) 4363434..4364030 - 597 WP_054176702.1 molecular chaperone -
M2R49_RS21065 (M2R49_21050) 4364075..4364848 - 774 WP_054176703.1 dimethyl sulfoxide reductase anchor subunit -
M2R49_RS21070 (M2R49_21055) 4364841..4365467 - 627 WP_042999104.1 dimethylsulfoxide reductase subunit B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(15-110)


Sequences

Toxin        


Download         Length: 159 a.a.        Molecular weight: 18341.95 Da        Isoelectric Point: 8.4403

>T244140 WP_044327726.1 NZ_CP096905:c4362346-4361870 [Citrobacter amalonaticus]
MDFPTWLNGWTIYAHPCFIDQYNALVARVEDLKHRFPDPIVFQKKKETKVLAHLLKSIANITHEPRASVYRPGDSIGKAY
TDWSRAKFGVERYRLFFRYSLESKIIVIAWVNDEGSLRTYGSKTDAYKIFGKMLDEGNPPDDWLSLLQACQNDGKEHL

Download         Length: 477 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12505.83 Da        Isoelectric Point: 4.1876

>AT244140 WP_042999108.1 NZ_CP096905:c4362686-4362351 [Citrobacter amalonaticus]
MFAYVRSEDIAIEADSKLTERHQTTIPASIRDALHLRSGDRIHYTLLSTGEVLLSKYSEATEDGVMRSFLDFLSQDVANN
PQTLKKLDLSRGYELVDGIDVNLDDEISDED

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q8DNJ3

References