Detailed information of TA system TA024414

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 2046239..2046714
• Replicon: chromosome
• Accession: NC_013450
• Organism: Staphylococcus aureus subsp. aureus ED98

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: SAAV_RS10365
• Protein ID: WP_000387655.1
• Coordinates: 2046239..2046541 (-)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2046590..2046714 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAAV_RS10350	2042059..2043012	-	954	WP_000766912.1	ornithine cyclodeaminase family protein	-
SAAV_RS10355	2043689..2044429	-	741	WP_000185611.1	CPBP family intramembrane metalloprotease	-
SAAV_RS10360	2044774..2046228	-	1455	WP_000930251.1	N-acetylmuramoyl-L-alanine amidase	-
SAAV_RS10365	2046239..2046541	-	303	WP_000387655.1	phage holin	Toxin
-	2046590..2046714	+	125	-	-	Antitoxin
SAAV_RS10370	2046739..2046886	-	148	Protein_1958	putative holin-like toxin	-
SAAV_RS10375	2047080..2047379	-	300	WP_000466781.1	DUF2951 family protein	-
SAAV_RS10380	2047425..2047589	-	165	WP_000916020.1	XkdX family protein	-
SAAV_RS10385	2047582..2047971	-	390	WP_001166602.1	DUF2977 domain-containing protein	-
SAAV_RS10390	2047971..2049437	-	1467	WP_000067150.1	BppU family phage baseplate upper protein	-
SAAV_RS10395	2049437..2051347	-	1911	WP_000429548.1	hypothetical protein	-
SAAV_RS10400	2051363..2051653	-	291	WP_000179860.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / groEL	2044774..2097043	52269

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (1-71)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11127.85 Da
• Isoelectric Point: 9.6587

>T24414 WP_000387655.1 NC_013450:c2046541-2046239 [Staphylococcus aureus subsp. aureus ED98]
MEAKVITRYIVLILALVNQFLANKGISPIPVDEESVSSIILTVIALYTTYKDNPTSQEGRWANQKLKKYKAESKYRKATG
QAPVKEVIAPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T24414 NC_013450:c2046541-2046239 [Staphylococcus aureus subsp. aureus ED98]
ATGGAAGCAAAAGTAATAACAAGATATATTGTATTAATTTTAGCATTAGTCAATCAGTTTTTAGCGAATAAAGGTATAAG
TCCGATACCAGTAGATGAAGAAAGTGTTTCATCGATTATCTTAACAGTTATTGCTTTATACACTACGTATAAAGACAATC
CAACATCACAAGAAGGACGTTGGGCGAATCAAAAATTAAAGAAATATAAAGCTGAAAGTAAATATAGAAAAGCAACAGGT
CAAGCACCTGTCAAAGAAGTAATAGCACCTACAAATATGAACGATACAAATGATTTAGGGTAG

Antitoxin

Nucleotide

• Length: 125 bp

>AT24414 NC_013450:2046590-2046714 [Staphylococcus aureus subsp. aureus ED98]
ATTTGATATTTATATTATGATGTGTTAATTTATATATAGAAAAAGGGCAACATGCGGAAACATGTCACCCTAGTGAGCCC
GTTAAAAAGACGGTGACCTCTTTTATATGATTAATAAATAACCAT

Structures

Antitoxin