Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2408643..2409205 Replicon chromosome
Accession NZ_CP096905
Organism Citrobacter amalonaticus strain RSHH22

Toxin (Protein)


Gene name higB Uniprot ID A0A3S7DBL2
Locus tag M2R49_RS11540 Protein ID WP_043000694.1
Coordinates 2408643..2408921 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M2R49_RS11545 Protein ID WP_043000693.1
Coordinates 2408921..2409205 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2R49_RS11520 (M2R49_11505) 2403768..2404199 - 432 WP_043000697.1 peroxiredoxin OsmC -
M2R49_RS11525 (M2R49_11510) 2404427..2404570 + 144 WP_042319017.1 stationary-phase-induced ribosome-associated protein -
M2R49_RS11530 (M2R49_11515) 2404742..2406439 + 1698 WP_044257943.1 malate dehydrogenase -
M2R49_RS11535 (M2R49_11520) 2406748..2408463 + 1716 WP_054177019.1 ABC-F family ATP-binding cassette domain-containing protein -
M2R49_RS11540 (M2R49_11525) 2408643..2408921 + 279 WP_043000694.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M2R49_RS11545 (M2R49_11530) 2408921..2409205 + 285 WP_043000693.1 HigA family addiction module antitoxin Antitoxin
M2R49_RS11550 (M2R49_11535) 2409250..2409852 - 603 WP_044257938.1 inorganic diphosphatase -
M2R49_RS11555 (M2R49_11540) 2409979..2410635 - 657 WP_043000691.1 formate dehydrogenase-N subunit gamma -
M2R49_RS11560 (M2R49_11545) 2410628..2411512 - 885 WP_043000690.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10573.12 Da        Isoelectric Point: 8.9461

>T244130 WP_043000694.1 NZ_CP096905:2408643-2408921 [Citrobacter amalonaticus]
MIMNFRHKGLRDLFLHGKTSGVLAKHVKRLRHRLAVIDAAGCVNDINMPGYRLHPLSGDRDGVWSISVSGNWRMTFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10370.07 Da        Isoelectric Point: 10.2982

>AT244130 WP_043000693.1 NZ_CP096905:2408921-2409205 [Citrobacter amalonaticus]
MKMANHPRPGDIIQEALDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPEMWLNLQNTWSLAQAQ
KSVDVSRLRRLAVQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S7DBL2

Antitoxin

Source ID Structure

References