Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4889964..4890566 Replicon chromosome
Accession NZ_CP096902
Organism Escherichia coli strain RSHH22

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag M1Y13_RS23950 Protein ID WP_000897305.1
Coordinates 4890255..4890566 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M1Y13_RS23945 Protein ID WP_000356397.1
Coordinates 4889964..4890254 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1Y13_RS23920 (4885890) 4885890..4886792 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
M1Y13_RS23925 (4886789) 4886789..4887424 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
M1Y13_RS23930 (4887421) 4887421..4888350 + 930 WP_000027706.1 formate dehydrogenase accessory protein FdhE -
M1Y13_RS23935 (4888680) 4888680..4888922 - 243 WP_001087409.1 protein YiiF -
M1Y13_RS23940 (4889141) 4889141..4889359 - 219 WP_001295676.1 CopG family transcriptional regulator -
M1Y13_RS23945 (4889964) 4889964..4890254 - 291 WP_000356397.1 NadS family protein Antitoxin
M1Y13_RS23950 (4890255) 4890255..4890566 - 312 WP_000897305.1 hypothetical protein Toxin
M1Y13_RS23955 (4890795) 4890795..4891703 + 909 WP_001162704.1 alpha/beta hydrolase -
M1Y13_RS23960 (4891767) 4891767..4892708 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
M1Y13_RS23965 (4892753) 4892753..4893190 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
M1Y13_RS23970 (4893187) 4893187..4894059 - 873 WP_000920762.1 virulence factor BrkB family protein -
M1Y13_RS23975 (4894053) 4894053..4894652 - 600 WP_001295269.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T244122 WP_000897305.1 NZ_CP096902:c4890566-4890255 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT244122 WP_000356397.1 NZ_CP096902:c4890254-4889964 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References