Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 594479..595278 Replicon chromosome
Accession NZ_CP096902
Organism Escherichia coli strain RSHH22

Toxin (Protein)


Gene name yhaV Uniprot ID F4VJD3
Locus tag M1Y13_RS02890 Protein ID WP_000347266.1
Coordinates 594479..594943 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag M1Y13_RS02895 Protein ID WP_001307405.1
Coordinates 594943..595278 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1Y13_RS02860 (589480) 589480..589914 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
M1Y13_RS02865 (589932) 589932..590810 - 879 WP_001315856.1 PTS N-acetylgalactosamine transporter subunit IID -
M1Y13_RS02870 (590800) 590800..591579 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
M1Y13_RS02875 (591590) 591590..592063 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
M1Y13_RS02880 (592086) 592086..593366 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
M1Y13_RS02885 (593615) 593615..594424 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
M1Y13_RS02890 (594479) 594479..594943 - 465 WP_000347266.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
M1Y13_RS02895 (594943) 594943..595278 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
M1Y13_RS02900 (595427) 595427..596998 - 1572 WP_001273741.1 galactarate dehydratase -
M1Y13_RS02905 (597373) 597373..598707 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
M1Y13_RS02910 (598723) 598723..599493 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17841.18 Da        Isoelectric Point: 9.4947

>T244090 WP_000347266.1 NZ_CP096902:c594943-594479 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRFFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT244090 WP_001307405.1 NZ_CP096902:c595278-594943 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836NGD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References