Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2236424..2237343 Replicon chromosome
Accession NZ_CP096848
Organism Mycobacterium tuberculosis variant bovis strain Mb0486

Toxin (Protein)


Gene name HigB2 Uniprot ID L7N4R2
Locus tag M1778_RS10485 Protein ID WP_003900449.1
Coordinates 2236738..2237343 (-) Length 202 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID L7N5K9
Locus tag M1778_RS10480 Protein ID WP_003410124.1
Coordinates 2236424..2236729 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1778_RS10450 (M1778_10450) 2231435..2232691 - 1257 WP_003410095.1 HNH endonuclease signature motif containing protein -
M1778_RS10455 (M1778_10455) 2233045..2233620 + 576 WP_079367746.1 hypothetical protein -
M1778_RS10460 (M1778_10460) 2233617..2234657 + 1041 WP_038438635.1 ImmA/IrrE family metallo-endopeptidase -
M1778_RS10465 (M1778_10465) 2234899..2235618 + 720 WP_010950643.1 DUF433 domain-containing protein -
M1778_RS10470 (M1778_10470) 2235608..2236024 + 417 WP_003410114.1 hypothetical protein -
M1778_RS10475 (M1778_10475) 2236040..2236339 - 300 WP_003410120.1 hypothetical protein -
M1778_RS10480 (M1778_10480) 2236424..2236729 - 306 WP_003410124.1 XRE family transcriptional regulator Antitoxin
M1778_RS10485 (M1778_10485) 2236738..2237343 - 606 WP_003900449.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M1778_RS10490 (M1778_10490) 2237368..2237727 - 360 WP_003410131.1 hypothetical protein -
M1778_RS10495 (M1778_10495) 2237887..2238540 - 654 WP_014324107.1 hypothetical protein -
M1778_RS10500 (M1778_10500) 2238516..2238752 - 237 WP_003410133.1 hypothetical protein -
M1778_RS10505 (M1778_10505) 2238959..2239855 - 897 WP_003410136.1 hypothetical protein -
M1778_RS10510 (M1778_10510) 2240039..2241187 - 1149 Protein_2077 helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(86-181)

Antitoxin

HigA2-like, helix-turn-helix domain

(32-92)


Sequences

Toxin        


Download         Length: 202 a.a.        Molecular weight: 22744.96 Da        Isoelectric Point: 7.3073

>T244058 WP_003900449.1 NZ_CP096848:c2237343-2236738 [Mycobacterium tuberculosis variant bovis]
VNVPWENAHGGALYCLIRGDEFSAWHRLLFQRPGCAESVLACRHFLDGSPVARCSYPEEYHPCVISRIALLCDSVGWTAD
VERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAG
NKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG

Download         Length: 606 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11291.91 Da        Isoelectric Point: 10.7482

>AT244058 WP_003410124.1 NZ_CP096848:c2236729-2236424 [Mycobacterium tuberculosis variant bovis]
MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYV
SALGGELDITVRLGDETFTLA

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BV20

Antitoxin

Source ID Structure
PDB 7EWC
PDB 7EWD
PDB 7EWE
AlphaFold DB A0A7U4BV30

References